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  Newsletter Issue V, 2004 

Dear Specs.net user,

Welcome to the December Specs.net newsletter!
In this issue:

1 - Building Blocks offered by Specs Research
2 - December 2004 Compound Library available
3 - Consortium Who? What? When? Where? Why?

4 - DMSO Solubility Prediction Software
5 Now specs.net order with SD file
Prices 2005

1 - Building Blocks offered by Specs Research Laboratory 

NEW! Now available: building blocks from the Specs Research Laboratory. A selection of building blocks that Specs Research Laboratory has synthesized over the years, are now presented in a downloadable database on www.specs.net. Available formats, delivery times (approximate), and price codes are also indicated. Of course, if you do not find the building block you are looking for, just send your inquiry for a custom synthesis to info@specs.net.

 - December 2004 Compound Library available

The December update of the complete Specs Compound Library is available on our website www.specs.net. Just login using your personal account details and download the library from the  Available Databases directory on the 'Upload/Download' page.

The December 2004 Compound Library release includes the following:

169.964 Screening Compounds (20 mg and more)
7.117 Building Blocks
391 Natural Products
Download the latest database of Screening Compounds, Building Blocks, Natural Products, Pre-plated Libraries or only the new entries since the last release of November 2004. You can choose your preferred format. In case you don't have a personal account yet or would like an additional account for your colleague, just register as a new user and within 24 hours you will receive your personal login data.
To automate the monthly Compound Library update downloads via our dedicated FTP mirror, please send a request to the specs.net technical support desk (support@specs.net) or to your sales representative at Specs. You will receive an account on the FTP mirror which will enable you to perform automated retrieval of our latest database updates.
For more information on compounds available in smaller quantities (minimum amount 1 mg), do not hesitate to contact our sales department (sales@specs.net).

3 - Consortium Who? What? When? Where? Why? 

Who? What? When? Where? Why?

Who? Any company involved with high throughput screening, planning on expanding their library, companies planning to start screening and looking for a large diverse library to start with.

What? A consortium is a limited number of companies with the objective of purchasing a large number of screening compounds at a low price. The consortium members all agree on the same number of compounds, the same format and the same structures.

When? When there are enough companies interested in purchasing the sets, and have supplied their purchase orders, we will then begin with the process.

Where? All the compounds will be shipped from Specs to anywhere in the world, plated in 96 well plates, either as a dry film or frozen in DMSO.

Why? With the increased need for new chemical entities (NCE) in the market, we are offering an opportunity for companies to find unique starting points in their drug discovery process. This will be advantageous for you also when the time arises for structure activity relation (SAR) work as it can be done with the confidence of security at the Specs Research Laboratory. The companies involved will also gain many major advantages. One such advantage is diverting away from the pre-plated targeted set-focussed library option. We have noticed that while pre-plated sets of those libraries are popular, companies who have the same target are purchasing the exact same set of compounds as their direct competitor. By screening of a diverse library, you will benefit by finding many different unique starting points, as the set can be used in many different screens for different targets.

Are you interested, contact us at info@specs.net.

4 - DMSO Solubility Prediction Software

December 14th is the last day to download and use the free demo version of the DMSO prediction software of Pharma Algorithms. As DMSO solubility is a hot issue in sample management and global drug discovery at this moment, Specs and Pharma Algorithms have combined their expertise to develop software predicting the solubility of compounds in DMSO.

During the past years Specs collected valuable data by plating 6.6 million samples, which represent more than 395.000 unique compounds. For the development of this predictive software about 20.000 compounds of the highest purity (>95%) were selected as a training set with the solubility cut-off volume set at 20 mM. Specs and Pharma Algorithms are planning to continue improving the model systematically.

A free demo version of this software is still available. You can request a copy by contacting us via info@specs.net or logon to Specs.net and download this free evaluation version from the 'Public files' folder in your Download menu.

5 Now specs.net order with SD file

In response to needs of our customers we have implemented new functionality on specs.net. It is now possible to download SD files containing structures of in your shopping basket or in your final order. This functionality is available for a single compound or for a list of compounds. In the future, more functionalities will be added to specs.net. If you have any suggestions, please email them to us at info@specs.net.

Prices 2005

For 2005 we anticipate an adjustment in the prices of our screening compounds. The new pricing structure will effect the orders for small number of compounds the most. Specs will introduce a pricing matrix, whereby prices will be determined not only by quantity ordered but also by the number of compounds ordered.

Contact us:

info@specs.net: General information (questions, comments, suggestions, etc.)
support@specs.netSupport for technical questions
unsubscribe@specs.net: To unsubscribe from Specs Newsletter

Best regards,
The Specs.net Team

P.S: If you think that friends or colleagues might find Specs.net useful, don't hesitate to forward this message!


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