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 Specs.net Newsletter Issue III, 2007
Dear Specs.net user,
Welcome to the November 2007 issue of the Specs.net newsletter!
In this issue:
1 - Specs expands Compound Management capacity in Delft
2 - Sample management in BioBanking
3 - Progress on the synthesis of cLogP compounds
4 - Specs on tour
5 - New Compound Library available


1 - Specs expands Compound Management capacity in Delft
At this moment we are expanding the Compound Management capacity at the Delft Headquarters to meet the demand for third party 'off-site' compound management projects. The expansion involves extra square meters, personnel and equipment a.o. balances and weighing cabinets.
The weighing cabinets have been designed based on the requirements specific to Specs' compound management operation. This means they allow optimal working conditions and safety, but also allows them to be easily transported to other locations for customer 'on-site' projects. For further information on our capabilities and references of previously performed turn-key projects please contact our sales representatives via info@specs.net.



2 - Sample management in BioBanking

During the last decade, partly due to the advances on the human genome research, an increasing amount of biological samples such as blood, urine, tissue's, DNA samples etc. are collected in specialized stores called 'biobanks' or 'biorepositories'.

Because of the comparable storage issue's involved in the process of biobanking, Specs has become active in the sample management of biologicals too. Although biological samples are different from chemical samples, the logistic challenges are often the same.

With the use of our in-house developed software and the long track record in processing large sample collections, the step into BioBanking has been very simple and effective. Last year we completed some exclusive projects in this area. Contact us via info@specs.net if you would like to find out more about what services we could offer your company in this area.

3 - Progress on the synthesis of cLogP compounds
As mentioned in one of our previous Newsletters the Specs Research Laboratory (SRL) is working on a research project with the acronym "cLogP" (Compound Libraries of Geminated Parts).

In this project new compounds are synthesized for traditional high throughput screening and fragment based screening campaigns. Small sized molecules with 2 or 3 reactive handles (parts) are coupled to other parts to obtain a relatively small screening compound (geminated parts) that can be optimized easily. By changing the coupling reaction same parts can result in a different product.

At this moment 63 unique parts have been synthesized and 5 coupling reactions (a.o. Mitsunobu, Buchwald) have been tested to form ethers, amines and amides. In total 49 geminated parts have been synthesized of the virtually over 1,000 possible combinations. Next step is standardization of the purification of the products. Intelligent combining of reagents and using resin-bound reagents simplifies the purification. For more information, please contact Specs at info@specs.net.

4 - Specs on tour
  • Innovating Lead Discovery, December 4-5, 2007, Holiday Inn Munich City Center, Munich (Germany)
  • LabAutomation 2008, January 27-30, 2008, Palm Springs Convention Center,
    Palm Springs (California, USA)
  • SBS 2008, April 6-10, 2008, America's Center, St. Louis, (Missouri, USA)
If you would like to set up a meeting with one of our representatives, please send an e-mail to info@specs.net.
5 - New Compound Library available

The latest update of the complete Specs Compound Library is available via our website www.specs.net. Just login using your personal account details and download the library from the Available Databases directory on the 'Upload/Download' page.


The November 2007 Compound Library release includes the following:

- 198.840 Screening Compounds (10 mg and more)
- 7.894 Building Blocks
- 324 Natural Products

You have the choice to download the latest database of Screening Compounds, Building Blocks, Natural Products, Pre-plated Libraries or only the new entries since the former web-release. You can also choose your preferred format.


In case you don't have a personal account yet or would like an additional account for your colleague, just register as a new user and within 24 hours you will receive your personal login data.


For more information on compounds available in smaller quantities (minimum amount 1 mg), do not hesitate to contact our sales department (info@specs.net).


Contact us:
info@specs.net:                  General information (questions, comments, suggestions, etc.)
support@specs.net:            Support for technical questions
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Best regards,
The Specs.net Team
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